Layers

The Nyespa (also known as "Layers" or "Humors") are a new concept introduced in Pathologic 2 that refer to systems that govern the body, and seem to loosely correspond to human organ systems. There are three Nyespa: Bile, Phlegm, and Wind. Bile seems to correspond to the digestive system and possibly the circulatory system, and "is said to be responsible for hatred and internal cycles." Phlegm seems to correspond to the nervous system, and "nests inside one’s head and hinders clear perception." Wind seems to correspond to the respiratory system and "is said to be cold and clingy." It is said that "when illness strikes, there is strife among the trio, and the disease kills." The tinctures brewed by the Haruspex can be used to reveal which of the three Nyespa are affected in those infected with the plague.

Each type of antibiotic can only target conditions of one of the Layers. Conditions related to the bile humor are cured by keto pills; conditions related to the phlegm humor are cured by beta pills; and conditions related to the wind humor are cured by tetra pills.