Layers

The Nyespa (also known as "Layers" or "Humors") are a new concept introduced in Pathologic 2. Nyespa refer to humors that govern the body, and are based on the Nyespas of Tibetan medicine. There are three Nyespa: Bile, Phlegm, and Wind. Bile "is said to be responsible for hatred and internal cycles.". Phlegm "nests inside one’s head and hinders clear perception." Wind "is said to be cold and clingy." It is said that "when illness strikes, there is strife among the trio, and the disease kills." The tinctures brewed by the Haruspex can be used to reveal which of the three Nyespa are affected in those infected with the plague.

Each type of antibiotic can only target conditions of one of the Layers. Conditions related to the bile humor are cured by keto pills; conditions related to the phlegm humor are cured by beta pills; and conditions related to the wind humor are cured by tetra pills.